abstract：:Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic...

journal_title：Cell metabolism

authors： López M,Lage R,Saha AK,Pérez-Tilve D,Vázquez MJ,Varela L,Sangiao-Alvarellos S,Tovar S,Raghay K,Rodríguez-Cuenca S,Deoliveira RM,Castañeda T,Datta R,Dong JZ,Culler M,Sleeman MW,Alvarez CV,Gallego R,Lelliott CJ,Carlin

更新日期：2008-05-01 00:00:00

abstract：:BAD, a proapoptotic member of the Bcl-2 family of proteins, is regulated by phosphorylation. A recent study (Danial et al., 2008) suggests a phosphorylation-state-dependent bifunctional role of BAD in the regulation of glucose-stimulated insulin secretion and beta cell mass. ...

journal_title：Cell metabolism

authors： Philipson LH,Roe MW

更新日期：2008-04-01 00:00:00

abstract：:While adipogenesis is known to be controlled by a complex network of transcription factors, less is known about the transcriptional cascade that initiates this process. We report here the characterization of Krüppel-like factor 4 (KLF4) as an essential early regulator of adipogenesis. Klf4 is expressed in 3T3-L1 cells...

journal_title：Cell metabolism

authors： Birsoy K,Chen Z,Friedman J

更新日期：2008-04-01 00:00:00

abstract：:Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycer...

journal_title：Cell metabolism

authors： Friedman SL,Nieto N

更新日期：2008-03-01 00:00:00

abstract：:Despite the prevalence of obesity and its related diseases, the signaling pathways for appetite control and satiety are not clearly understood. Here we report C. elegans quiescence behavior, a cessation of food intake and movement that is possibly a result of satiety. C. elegans quiescence shares several characteristi...

journal_title：Cell metabolism

authors： You YJ,Kim J,Raizen DM,Avery L

更新日期：2008-03-01 00:00:00

abstract：:Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates ...

journal_title：Cell metabolism

authors： Schwer B,Verdin E

更新日期：2008-02-01 00:00:00

abstract：:The adult skeleton is constantly renewed through bone remodeling. Four recent papers (Baldock et al., 2007; Lee et al., 2007; Lundberg et al., 2007; Sato et al., 2007) provide new insights into central and peripheral control of this remodeling sequence. Two of the studies add to our knowledge of the complex hypothalam...

journal_title：Cell metabolism

authors： Rosen CJ

更新日期：2008-01-01 00:00:00

abstract：:Animal studies have revealed brain regions that control homeostatic feeding, but the rampant overeating contributing to the obesity epidemic suggests the participation of "nonhomeostatic" control centers. Recent papers by Batterham et al. (2007) and Farooqi et al. (2007) link peptide YY(3-36) and leptin to the activat...

journal_title：Cell metabolism

authors： Grill HJ,Skibicka KP,Hayes MR

更新日期：2007-12-01 00:00:00

abstract：:Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and c...

journal_title：Cell metabolism

authors： Idle JR,Gonzalez FJ

更新日期：2007-11-01 00:00:00

abstract：:In type 2 diabetes, pancreatic beta cells fail to secrete sufficient insulin to overcome peripheral insulin resistance. Intracellular lipid accumulation contributes to beta cell failure through poorly defined mechanisms. Here we report a role for the lipid-regulated protein kinase C isoform PKCepsilon in beta cell dys...

journal_title：Cell metabolism

authors： Schmitz-Peiffer C,Laybutt DR,Burchfield JG,Gurisik E,Narasimhan S,Mitchell CJ,Pedersen DJ,Braun U,Cooney GJ,Leitges M,Biden TJ

更新日期：2007-10-01 00:00:00

abstract：:Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging. ...

journal_title：Cell metabolism

authors： Bartke A

更新日期：2007-09-01 00:00:00

abstract：:Nuclear receptor signaling plays an important role in energy metabolism. In this study we demonstrate that the nuclear receptor corepressor RIP140 is a key regulator of metabolism in skeletal muscle. RIP140 is expressed in a fiber type-specific manner, and manipulation of its levels in null, heterozygous, and transgen...

journal_title：Cell metabolism

authors： Seth A,Steel JH,Nichol D,Pocock V,Kumaran MK,Fritah A,Mobberley M,Ryder TA,Rowlerson A,Scott J,Poutanen M,White R,Parker M

更新日期：2007-09-01 00:00:00

abstract：:The role of microbial load during aging of the adult fruit fly Drosophila melanogaster is incompletely understood. Here we show dramatic increases in aerobic and anaerobic bacterial load during aging, both inside the body and on the surface. Scanning electron microscopy and cell staining analyses of the surface of age...

journal_title：Cell metabolism

authors： Ren C,Webster P,Finkel SE,Tower J

更新日期：2007-08-01 00:00:00

abstract：:Conservation of the rapamycin-sensitive TOR signaling network among eukaryotes has been instrumental to the rapid progress made in this field in recent years. A recent report in Molecular Cell (Urban et al., 2007) now extends this conservation to include Sch9, an AGC protein kinase family member from S. cerevisiae, wh...

journal_title：Cell metabolism

authors： Powers T

更新日期：2007-07-01 00:00:00

abstract：:Food intake and activity-induced thermogenesis are important components of energy balance regulation. The molecular mechanism underlying the coordination of food intake with locomotory behavior to maintain energy homeostasis is unclear. We report that the brain-specific homeobox transcription factor Bsx is required fo...

journal_title：Cell metabolism

authors： Sakkou M,Wiedmer P,Anlag K,Hamm A,Seuntjens E,Ettwiller L,Tschöp MH,Treier M

更新日期：2007-06-01 00:00:00

abstract：:The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are required for ve...

journal_title：Cell metabolism

authors： Tong Q,Ye C,McCrimmon RJ,Dhillon H,Choi B,Kramer MD,Yu J,Yang Z,Christiansen LM,Lee CE,Choi CS,Zigman JM,Shulman GI,Sherwin RS,Elmquist JK,Lowell BB

更新日期：2007-05-01 00:00:00

abstract：:Nucleotide-specific isoforms of the tricarboxylic acid (TCA) cycle enzyme succinyl-CoA synthetase (SCS) catalyze substrate-level synthesis of mitochondrial GTP (mtGTP) and ATP (mtATP). While mtATP yield from glucose metabolism is coupled with oxidative phosphorylation and can vary, each molecule of glucose metabolized...

journal_title：Cell metabolism

authors： Kibbey RG,Pongratz RL,Romanelli AJ,Wollheim CB,Cline GW,Shulman GI

更新日期：2007-04-01 00:00:00

abstract：:GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid depr...

journal_title：Cell metabolism

authors： Towle HC

更新日期：2007-02-01 00:00:00

abstract：:Components involved in vesicle trafficking processes such as secretion, endocytosis, and autophagy are gaining recognition as important regulators and effectors of target of rapamycin (TOR) signaling. A recent report by now implicates Pmr1, a secretory pathway Ca(2+)/Mn(2+) ATPase located in the Golgi apparatus, as a ...

journal_title：Cell metabolism

authors： Neufeld TP

更新日期：2007-01-01 00:00:00

abstract：:Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are not completely understood. We demonstrate that TNFalpha signaling through TNF receptor (TNFR) 1 suppresses AMPK activity via transcriptional upregulation o...

journal_title：Cell metabolism

authors： Steinberg GR,Michell BJ,van Denderen BJ,Watt MJ,Carey AL,Fam BC,Andrikopoulos S,Proietto J,Görgün CZ,Carling D,Hotamisligil GS,Febbraio MA,Kay TW,Kemp BE

更新日期：2006-12-01 00:00:00

abstract：:Most animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in mediating the physiological effects of vagal activation. Here, we tested the hypo...

journal_title：Cell metabolism

authors： Gautam D,Gavrilova O,Jeon J,Pack S,Jou W,Cui Y,Li JH,Wess J

更新日期：2006-11-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target. We tested the hypothesis that blockade of the NPY5R will lead to weight loss in humans using MK-0557, a potent, highly selective, orally active...

journal_title：Cell metabolism

authors： Erondu N,Gantz I,Musser B,Suryawanshi S,Mallick M,Addy C,Cote J,Bray G,Fujioka K,Bays H,Hollander P,Sanabria-Bohórquez SM,Eng W,Långström B,Hargreaves RJ,Burns HD,Kanatani A,Fukami T,MacNeil DJ,Gottesdiener KM,Ama

更新日期：2006-10-01 00:00:00

abstract：:The trace element copper (Cu) is a cofactor for biochemical functions ranging from energy generation to iron (Fe) acquisition, angiogenesis, and free radical detoxification. While Cu is essential for life, the molecules that mediate dietary Cu uptake have not been identified. Ctr1 is a homotrimeric protein, conserved ...

journal_title：Cell metabolism

authors： Nose Y,Kim BE,Thiele DJ

更新日期：2006-09-01 00:00:00

abstract：:Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of Socs-3, or those with neuronal deletion of Socs-3, are lean and more leptin and insulin sensitive. To examine the role of Socs-3 within...

journal_title：Cell metabolism

authors： Kievit P,Howard JK,Badman MK,Balthasar N,Coppari R,Mori H,Lee CE,Elmquist JK,Yoshimura A,Flier JS

更新日期：2006-08-01 00:00:00

abstract：:The PAR-domain basic leucine zipper (PAR bZip) transcription factors DBP, TEF, and HLF accumulate in a highly circadian manner in several peripheral tissues, including liver and kidney. Mice devoid of all three of these proteins are born at expected Mendelian ratios, but are epilepsy prone, age at an accelerated rate,...

journal_title：Cell metabolism

authors： Gachon F,Olela FF,Schaad O,Descombes P,Schibler U

更新日期：2006-07-01 00:00:00

abstract：:One of the hallmarks of type 2 diabetes is that pancreatic beta cells fail to release sufficient amounts of insulin in the presence of elevated blood glucose levels. Insulin secretion is modulated by many hormones and neurotransmitters including acetylcholine, the major neurotransmitter of the peripheral parasympathet...

journal_title：Cell metabolism

authors： Gautam D,Han SJ,Hamdan FF,Jeon J,Li B,Li JH,Cui Y,Mears D,Lu H,Deng C,Heard T,Wess J

更新日期：2006-06-01 00:00:00

abstract：:Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Pemt(-/-) mice fed a choline-deficient (CD) diet develop rapid steatohepatitis ...

journal_title：Cell metabolism

authors： Li Z,Agellon LB,Allen TM,Umeda M,Jewell L,Mason A,Vance DE

更新日期：2006-05-01 00:00:00

abstract：:What are the pathways that underlie the coordinated responses of an organism to well-fed and food-deprived states? A report in this issue of Cell Metabolism suggests that starvation functions via a muscarinic acetylcholine receptor to activate MAP kinase signaling in the pharyngeal muscle of C. elegans (You et al., 20...

journal_title：Cell metabolism

authors： Ashrafi K

更新日期：2006-04-01 00:00:00

abstract：:By locally infecting epididymal adipocytes of obese diabetic mice with the uncoupling protein-1 transgene, Yamada et al. (2006[this issue of Cell Metabolism]) unexpectedly induce leptin sensitivity with hypophagia and improvement in abnormal glucose and lipid abnormalities. ...

journal_title：Cell metabolism

authors： Unger RH,Elmquist JK

更新日期：2006-03-01 00:00:00

abstract：:Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a powerful technique for their functionalization. To uncover the role of the liver-specific miR-122 in the adult liver, we inhibited it in mice with a 2'-O-methoxyethyl phosphorothioate ASO. miR-12...

journal_title：Cell metabolism

authors： Esau C,Davis S,Murray SF,Yu XX,Pandey SK,Pear M,Watts L,Booten SL,Graham M,McKay R,Subramaniam A,Propp S,Lollo BA,Freier S,Bennett CF,Bhanot S,Monia BP

更新日期：2006-02-01 00:00:00

abstract：:The final steps in the production of adenosine triphosphate (ATP) in mitochondria are executed by a series of multisubunit complexes and electron carriers, which together constitute the oxidative phosphorylation (OXPHOS) system. OXPHOS is under dual genetic control, with communication between the nuclear and mitochond...

journal_title：Cell metabolism

authors： Smeitink JA,Zeviani M,Turnbull DM,Jacobs HT

更新日期：2006-01-01 00:00:00

abstract：:Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to improve metabolic and hormonal status of circadian rhythm sleep disorders, although its mechanism is poorly understood. In the present study, we revealed that light induces gene expression in the adrenal gland via the supra...

journal_title：Cell metabolism

authors： Ishida A,Mutoh T,Ueyama T,Bando H,Masubuchi S,Nakahara D,Tsujimoto G,Okamura H

更新日期：2005-11-01 00:00:00

abstract：:A hypothesis that accounts for most of the available literature on insulin-stimulated GLUT4 translocation is that insulin action controls the access of GLUT4 vesicles to a constitutively active plasma-membrane fusion process. However, using an in vitro fusion assay, we show here that fusion is not constitutively activ...

journal_title：Cell metabolism

authors： Koumanov F,Jin B,Yang J,Holman GD

更新日期：2005-09-01 00:00:00

abstract：:Reducing obesity requires an elevation of energy expenditure and/or a suppression of food intake. Here we show that enhancing hepatic glycolysis reduces body weight and adiposity in obese mice. Overexpression of glucokinase or 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is used to increase hepatic glycolysis....

journal_title：Cell metabolism

authors： Wu C,Kang JE,Peng LJ,Li H,Khan SA,Hillard CJ,Okar DA,Lange AJ

更新日期：2005-08-01 00:00:00

abstract：:The Saccharomyces cerevisiae chromatin silencing factor Sir2 suppresses genomic instability and extends replicative life span. In contrast, we find that mouse embryonic fibroblasts (MEFs) deficient for SIRT1, a mammalian Sir2 homolog, have dramatically increased resistance to replicative senescence. Extended replicati...

journal_title：Cell metabolism

authors： Chua KF,Mostoslavsky R,Lombard DB,Pang WW,Saito S,Franco S,Kaushal D,Cheng HL,Fischer MR,Stokes N,Murphy MM,Appella E,Alt FW

更新日期：2005-07-01 00:00:00

abstract：:Mammalian cells detect decreases in oxygen concentrations to activate a variety of responses that help cells adapt to low oxygen levels (hypoxia). One such response is stabilization of the protein HIF-1 alpha, a component of the transcription factor HIF-1. Here we show that a small interfering RNA (siRNA) against the ...

journal_title：Cell metabolism

authors： Brunelle JK,Bell EL,Quesada NM,Vercauteren K,Tiranti V,Zeviani M,Scarpulla RC,Chandel NS

更新日期：2005-06-01 00:00:00

abstract：:High-fat diets cause peripheral leptin resistance, and dietary lipid composition affects sensitivity to leptin. We examined the role of n-3 polyunsaturated fatty acid (PUFA) in peripheral leptin resistance. Dietary PUFAs (0.4% wt/wt) caused insensitivity to peripherally but not intracerebroventricularly administered l...

journal_title：Cell metabolism

authors： Oh-I S,Shimizu H,Sato T,Uehara Y,Okada S,Mori M

更新日期：2005-05-01 00:00:00

abstract：:Skeletal and cardiac muscle depend on high turnover of ATP made by mitochondria in order to contract efficiently. The transcriptional coactivator PGC-1alpha has been shown to function as a major regulator of mitochondrial biogenesis and respiration in both skeletal and cardiac muscle, but this has been based only on g...

journal_title：Cell metabolism

authors： Arany Z,He H,Lin J,Hoyer K,Handschin C,Toka O,Ahmad F,Matsui T,Chin S,Wu PH,Rybkin II,Shelton JM,Manieri M,Cinti S,Schoen FJ,Bassel-Duby R,Rosenzweig A,Ingwall JS,Spiegelman BM

更新日期：2005-04-01 00:00:00

abstract：:Leptin activates the long form of the leptin receptor (LRb) to control feeding and neuroendocrine function and thus regulate adiposity. While adiposity influences insulin sensitivity, leptin also regulates glucose homeostasis independently of energy balance. Disruption of the LRb/STAT3 signal in s/s mice results in hy...

journal_title：Cell metabolism

authors： Bates SH,Kulkarni RN,Seifert M,Myers MG Jr

更新日期：2005-03-01 00:00:00

abstract：:Almost always, obesity is an obligate prerequisite for the development of type 2 diabetes mellitus. Loss of a well-known lipid phosphatase appears to prevent insulin-resistant diabetes in mice by removal of a positive regulator of adiposity. ...

journal_title：Cell metabolism

authors： Birnbaum MJ

更新日期：2005-02-01 00:00:00